First introduced in 2009, the concept of "NAD World" provided a system-wide framework of how NAD⁺ affects the body’s ageing process.

Then came NAD World 2.0 in 2016, expanding the model to account for inter-organ communication, particularly between key metabolic centres like the hypothalamus, skeletal muscle, and adipose tissue.

Now, researchers have introduced NAD World 3.0: a more advanced theory that explains how extracellular NAMPT (eNAMPT) and NMN (nicotinamide mononucleotide) work together in feedback loops to regulate NAD⁺ levels across the entire body.

This development has significant implications, not just for scientists, but for anyone looking to maintain energy, cognitive clarity, and long-term metabolic health. And for those in the UK searching for the best NMN supplement, the evidence points to solutions that are potent, clinically dosed, and systemically targeted.

What is eNAMPT and Why Does it Matter?

At the centre of NAD World 3.0 is eNAMPT, short for extracellular nicotinamide phosphoribosyltransferase. It’s a key enzyme in the NAD⁺ salvage pathway, the body’s method of recycling used nicotinamide into NMN, which is then converted back into NAD⁺.

While NAMPT typically functions inside cells, eNAMPT is secreted into the bloodstream, acting almost like a hormone. It travels in extracellular vesicles and delivers instructions to distant tissues, including the brain and hypothalamus, which are particularly vulnerable to NAD⁺ decline with age. NIH researchers have outlined how eNAMPT modulates circadian rhythms and metabolic health via NAD⁺ signalling.

Higher eNAMPT activity has been linked to:

• Improved metabolic efficiency
  
  
• Better circadian rhythm regulation
  
  
• Slower age-associated deterioration
  
  

In short, eNAMPT is a systemic regulator of NAD⁺, its activity depends directly on NMN availability.

NAD World 3.0: Why it Matters for Supplement Users

For consumers interested in NMN supplements in the UK, the new NAD World model offers three key insights:

NMN SUPPLEMENTATION IS A VALIDATED STRATEGY FOR HEALTHY AGEING

With NMN now understood as a core player in NAD⁺ homeostasis, supplementation becomes more than a wellness trend, it’s a science-backed intervention. Research shows that boosting NMN levels can help maintain NAD⁺ across critical tissues, supporting:

• Cellular energy
  
  
• Cognitive health
  
  
• Metabolic flexibility
  
  
• DNA repair

NOT ALL NMN IS CREATED EQUAL

NAD World 3.0 shows that timing, purity, and dosing are vital. Simply taking high amounts of synthetic NMN may not produce the desired effect. The body’s ability to utilise NMN relies on bioavailability and molecular integrity, especially when aiming to influence systemic regulators like eNAMPT.

Look for NMN products that offer:

• 1000mg clinical dose
  
  
• High purity (≥99%)
  
  
• Stable beta-form (not racemic mixtures)
  
  
• Natural or enzymatic production methods

LONG-TERM BALANCE OVER SHORT-TERM BOOSTS

The model reminds us that NAD⁺ levels are dynamic, involving cross-talk between organs and tissues. The goal isn’t to flood the body with precursors, but to support long-term cellular resilience. Consistency, quality, and biological compatibility matter far more than megadoses. This systems-level view is supported by research from the Salk Institute, which highlights how circadian genes like REV‑ERBα interact with NAD⁺ metabolism to regulate whole-body energy balance.

Manapura® NMN: Science-Aligned, UK-Focused

At Manapura, we’ve formulated our NMN capsules to align with the latest science from NAD World 3.0, prioritising effectiveness, bioavailability, and purity.

Our 1000mg NMN doses are:

• Made using patented Enzymatic Synthesis – unlike many NMN supplements made through chemical synthesis, Manapura uses a cutting-edge natural enzymatic process. This ensures a cleaner, more bio-active product.
  
  
• 100% Beta-NMN – only the beta form of NMN is biologically active. Chemical methods often produce alpha isomers or racemic mixtures. Manapura's NMN contains only the bio-identical form your body can use.
  
  
• Potent and Pure – each dose of two capsules contains a full 1000mg of NMN, with ≥99.97% purity, independently tested and verified.
  
  
• Clinically dosed for daily use – not underdosed like many competitors. This is a full-strength, high-conversion NMN product that aligns with longevity research.
  
  
• UK-based with Free Shipping – no hidden import fees or customs delays. We are based in the UK, and offer fast, free shipping across the country.

Final Thoughts: The Future of Ageing Starts Now

The emergence of NAD World 3.0 offers a refined map of how our bodies regulate energy, repair, and longevity, through an intricate dance between NAD⁺, NMN, and eNAMPT.

Understanding this model empowers us to make smarter, more targeted choices when it comes to supplementation. And with Manapura® NMN, you’re not just buying a product, you’re investing in a science-aligned, bioavailable, UK-based solution designed for long-term cellular health.

Welcome to Manapura.