At Manapura, we do things differently. Our NMN is enzymatically produced, creating only the biologically active beta isomer. In this article, we’ll break down exactly why that matters, how enzymatic synthesis works, and what sets Manapura NMN apart from the rest.

Quick Primer: What is NMN and Why Does It Matter?

NMN (Nicotinamide Mononucleotide) is a precursor to NAD⁺ (Nicotinamide Adenine Dinucleotide), a coenzyme found in every cell of your body. NAD⁺ plays a key role in:

• Energy production via mitochondrial function
  
  
• DNA repair and genomic stability
  
  
• Sirtuin activation, a group of longevity-related proteins
  
  
• and Metabolic regulation

As we age, NAD⁺ levels decline dramatically (down to half the bodies initial levels by our mid-40s), leading to fatigue, metabolic dysfunction, and increased susceptibility to age-related diseases. Supplementing with NMN is one of the most direct and scientifically validated ways to restore NAD⁺ levels.

What Are Isomers and Why Should You Care?

Isomers are molecules with the same chemical formula but different structural arrangements – i.e. the atoms are arranged in the molecule differently.  In the case of NMN, there are two isomers:

• Beta-NMN (β-NMN): The natural, biologically active form used by human cells
  
  
• Alpha-NMN (α-NMN): An unnatural isomer with little to no biological function
  

Most chemically synthesised NMN products on the market produce a ‘racemic mix’ - containing both alpha and beta isomers. This reduces the bioavailability and potency of the supplement, as only beta-NMN can be converted into NAD⁺.

The Problem with Chemically Synthesised NMN

Chemical synthesis is the dominant manufacturing method in the supplement industry due to its low cost and scalability. This means there is a lot of cheaper NMN available on the market.  However, this cheaper product comes with significant downsides:

For consumers seeking maximum efficacy, purity, and bioavailability, chemically synthesised NMN falls short.

The Manapura Difference: Enzymatically Synthesised NMN

At Manapura, we use a patented enzymatic production process that mimics how NMN is created in nature. Using these biosynthesis enzymes to construct NMN results in precisely and exclusively the beta-form of NMN. 

‘NMN made via biological manufacturing process (enzymatic synthesis) is stereospecific to a beta form’
Shen et al., Biotechnology Letters 2021

This more natural, biological approach replicates what happen in our bodies.

“NMN synthesis via enzymatic methods mimics the reaction pathways of NAD+ and NMN in organisms.”
Tan et al., Frontiers in Microbiology, 2024

Scientific Support: Why Beta Isomer Matters

Multiple researchers worldwide have confirmed that only the beta-NMN isomer is metabolised efficiently by human cells to increase NAD⁺ levels. Alpha-NMN, on the other hand is biologically inactive and offers no measurable NAD⁺ boost.

“NMN itself consists of two isomers, namely the α-isomer and the β-isomer…. It is the β-isomer that functions as the active form of NMN and can be found in various organisms”
Wu et al., Molecules 2024

This confirms what biochemists have known for years: isomer specificity matters - especially when you’re paying a premium for longevity supplements.

Chemical Synthesis → ‘Racemic mix’ (α-NMN + β-NMN) → Lower NAD⁺

Enzymatic Synthesis → Pure β-NMN → High NAD⁺ boost

Other Reasons Why Enzymatic Synthesis Wins:

• Pharmaceutical-Grade Accuracy
  
  
• No Residual Solvents
  
  
• High Stability and Bioavailability
  
  
• Mimics Natural Human Biochemistry
  
  
• More Sustainable - eco-friendly as compared to chemical synthesis.
  

What to Look for in an NMN Product

When shopping for NMN, don’t just look at the dosage. Quality depends on several key factors:

• Synthesis Method (look for enzymatically synthesised)
  
  
• Purity Levels (Manapura tests at 99.97% purity)
  
  
• Isomer Specificity (100% beta-NMN)
  
  
• Number of Capsules, and Dose (mg) per capsule
  
  
• Third-Party Testing
  
  
• GMP-Certified Production

Manapura ticks all of these boxes - and provides third-party testing results for every batch.

What Else Makes Manapura NMN Stand Apart

If you’re using NMN to enhance longevity, energy, or cellular resilience, every detail counts. Choosing a pure beta-NMN product means you're actually getting what your cells can use. Anything less is just expensive filler.

Manapura NMN is exclusively the beta-isomer of NMN.  Further to this, Manapura NMN is;

• 99.97% Purity NMN, independently tested
  
  
• 30 x 1000mg doses (60 x 500mg capsules) per jar
  
  
• Manufactured in ISO 9001 and cGMP-certified facilities in the UK 
  
  
• Third-Party Tested in ILAC-MRA accredited labs
  
  
• Free from any fillers, binders, or synthetic preservatives
  
  
• Free and Fast Shipping to the USA, UK, and EU
  
  
• Sealed in pharmaceutical-grade glass vessels with added UV protection
  
  
• Packaged sustainably and responsibility - from the way we formulate our products to the way we package them.
  
  
• 100% kerbside recyclable packaging, made using compostable materials from managed forests and printed with water-based inks.
  

And with transparent batch testing and science-driven production, Manapura gives you clinical-grade confidence in every capsule.

Frequently Asked Questions

• Is enzymatic NMN more expensive?

  Yes, slightly - but for good reason. Enzymatic production is more precise, natural, and environmentally responsible. The result is a cleaner, more effective product.
  

• What does “100% beta isomer” mean?

  It means only the bioactive form of NMN is present. None of the inactive alpha isomer, no waste, and no guessing about efficacy.
  

• How can I be sure Manapura NMN is enzymatically synthesised?

  We’re fully transparent. Each batch is tested and documented with a COA (Certificate of Analysis), and is further third-party tested by accredited independent laboratories.
  

• Does this mean chemically synthesised NMN is unsafe?

  Not necessarily - but it is certainly less consistent and likely to be less potent per mg. 
  

• Alpha NMN vs Beta NMN?

  Both alpha-NMN and beta-NMN are structural forms (called isomers) of nicotinamide mononucleotide (NMN). The difference lies in how the molecule’s atoms are arranged. While they share the same chemical formula, only beta-NMN is found in the human body. Alpha-NMN is a mirror-image isomer that does not occur naturally, and is not used in our cells.
  

Final Thoughts

When it comes to NMN, isomer purity isn’t a technicality - it’s the difference between efficacy and inefficacy. With Manapura’s enzymatically synthesised, 100% beta-NMN, you’re investing in a supplement that aligns with your body’s biochemistry and your health-span goals.

Don’t settle for diluted, ‘racemic’ NMN. Choose the form your body recognises, absorbs, and uses.

Explore Manapura NMN – where purity, science, and transparency converge for your longevity.

Welcome to Manapura.